[Effects of alminoprofen on sodium urate crystal-induced inflammation].

Abstract

Effects of alminoprofen (AP), a non-steroidal anti-inflammatory agent, were investigated using several experimental gouty models. AP (3-30 mg/kg, p.o.) dose-dependently inhibited urate crystal-induced rat paw edema. AP (3-30 mg/kg, p.o.) inhibited the accumulation of exudate and decreased the total counts of leukocytes and the amount of PGE2 in a dose-dependent manner in sodium urate crystal-induced pleuritic rats. AP (0.3-10 mg/kg, p.o.) showed a dose-related analgesic activity on the pain response in sodium urate crystal-induced arthritic rats. AP (10(-5)-10(-3)M) inhibited the sodium urate crystal-induced beta-glucuronidase release from guinea pig neutrophils at more than 10(-4) M. AP (10(-5)-10(-3)M) did not inhibit the sodium urate crystal-induced production of O2- from guinea-pig neutrophils. AP (10(-6)-10(-4) M) inhibited dose-dependently the chemotaxis of leukocytes induced by chemotactic factors from guinea pig neutrophils stimulated with sodium urate crystals. AP (10(-6)-10(-4) M) inhibited the sodium urate crystal-induced production of PGE2 from rat peritoneal leukocytes in a dose-related manner. These results suggest that AP has a potent anti-inflammatory and analgesic activity in sodium urate crystal-induced inflammations, and these effects are exerted through its combined inhibitions of PGE2 synthesis, leukocyte chemotaxis and lysosomal enzyme release.

• Authors: E Maeda, T Hujiyoshi, T Uematsu
• Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica (Nihon Yakurigaku Zasshi) Vol. 98 Issue 6 Pg. 467-74 (Dec 1991) ISSN: 0015-5691 [Print] Japan
• PMID: 1783328 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Free Radicals
• Peroxides
• Propionates
• alminoprofen
• Uric Acid
• Glucuronidase
• Dinoprostone

Topics

• Animals
• Anti-Inflammatory Agents, Non-Steroidal (pharmacology, therapeutic use)
• Chemotaxis, Leukocyte (drug effects)
• Depression, Chemical
• Dinoprostone (biosynthesis)
• Dose-Response Relationship, Drug
• Free Radicals
• Glucuronidase (metabolism)
• Gout (chemically induced, drug therapy, metabolism)
• Guinea Pigs
• Male
• Neutrophils (metabolism)
• Peroxides (metabolism)
• Propionates (pharmacology, therapeutic use)
• Rats
• Rats, Inbred Strains
• Uric Acid