The potential role of chitin in allergic reactions.

Abstract

Allergy, a potentially life-threatening condition, has at its heart an overly zealous T-helper type 2 response to environmental antigens. We are constantly flooded by potential allergens, both airborne and ingested. Although innocuous to some, common antigens can cause serious allergic reactions in susceptible individuals. Chitin, a polymerized sugar and fundamental component of arthropods and fungi, is not commonly deemed a potential allergen but can cause sensitization through frequent exposure. A recent intriguing study has highlighted the role of chitin in allergic reactions.

• Authors: Oliver T Burton, Paola Zaccone
• Journal: Trends in immunology (Trends Immunol) Vol. 28 Issue 10 Pg. 419-22 (Oct 2007) ISSN: 1471-4906 [Print] England
• PMID: 17826333 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Allergens
• Chitin

Topics

• Allergens (immunology)
• Animals
• Chitin (chemistry, immunology)
• Humans
• Hypersensitivity (immunology, metabolism)
• Macrophage Activation
• Th2 Cells (immunology)