Effect of metal ion complexation and chalcogen donor identity on the antiproliferative activity of 2-acetylpyridine N,N-dimethyl(chalcogen)semicarbazones.

Abstract

Three chalcogensemicarbazones, viz., 2-acetylpyridine N,N-dimethylsemicarbazone (HL(1)), 2-acetylpyridine N,N-dimethylthiosemicarbazone (HL(2)) and 2-acetylpyridine N,N-dimethylselenosemicarbazone (HL(3)), their corresponding gallium(III) complexes [Ga(L(1-3))(2)]PF(6) and the ruthenium(III) compound [Ru(L(2))(2)]PF(6) have been prepared and characterised by X-ray crystallography and spectroscopic techniques (IR, UV/vis, (1)H, (13)C, (15)N, (77)Se NMR) in order to elucidate the effect of metal ion complexation and chalcogen donor identity on the cytotoxicity of chalcogensemicarbazones in two human tumour cell lines 41M (ovarian carcinoma) and SK-BR-3 (mammary carcinoma).

• Authors: Christian R Kowol, Rene Eichinger, Michael A Jakupec, Mathea S Galanski, Vladimir B Arion, Bernhard K Keppler
• Journal: Journal of inorganic biochemistry (J Inorg Biochem) Vol. 101 Issue 11-12 Pg. 1946-57 (11 2007) ISSN: 0162-0134 [Print] United States
• PMID: 17825917 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Chalcogens
• Metals
• Organometallic Compounds
• Thiosemicarbazones
• Ruthenium
• Gallium

Topics

• Antineoplastic Agents (chemical synthesis, chemistry, pharmacology)
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Chalcogens (chemistry)
• Crystallography, X-Ray
• Gallium (chemistry)
• Humans
• Metals (chemistry)
• Molecular Structure
• Organometallic Compounds (chemical synthesis, chemistry, pharmacology)
• Ruthenium (chemistry)
• Thiosemicarbazones (chemistry)