Early cardiac toxicity of 4'-iodo-4'-deoxydoxorubicin.

Abstract

4'-iodo-4'-deoxydoxorubicin was administered intravenously to 35 patients with advanced malignant neoplasms. The doses were escalated as follows: 2, 4, 6, 7, 10, 14, 19, 26, 52, 70, 80 and 90 mg/m2. Myocardial function was assessed by Holter monitoring and echocardiography. The prevalence of arrhythmias that could be attributed to the drug in the 24 h following infusion was 14.3% (supraventricular) and 10.6% (ventricular). Echocardiographic heart function variables were unchanged at 24 h and 21 days from drug injection. The data indicate the absence of significant, acute cardiotoxic effects of 4'-iodo-4'-deoxydoxorubicin.

• Authors: F Villani, M Galimberti, R Comazzi
• Journal: European journal of cancer (Oxford, England : 1990) (Eur J Cancer) Vol. 27 Issue 12 Pg. 1601-4 ( 1991) ISSN: 0959-8049 [Print] England
• PMID: 1782067 (Publication Type: Journal Article)

Chemical References

• 4'-deoxy-4'-iododoxorubicin
• Doxorubicin

Topics

• Adolescent
• Adult
• Aged
• Arrhythmias, Cardiac (chemically induced)
• Dose-Response Relationship, Drug
• Doxorubicin (adverse effects, analogs & derivatives)
• Female
• Humans
• Male
• Middle Aged
• Myocardial Contraction (drug effects)
• Neoplasms (drug therapy)
• Time Factors