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Antifungal activity of the new agent latoconazole in two tinea models.

Abstract
In vitro and in vivo antifungal activities of the new imidazole derivative latoconazole ((+-)-(E)-[4-(2-chlorophenyl)-1,3-dithiolan-2-ylidene]-1- imidazolylacetonitrile, NND-318; CAS 101530-10-3) were studied in comparison with three major topical agents, clotrimazole, bifonazole and tolnaftate. The in vitro activity of latoconazole against dermatophytes was much stronger than that of any reference agent tested. Both the recently developed tinea pedis model and the conventional tinea model in guinea pigs were employed for evaluation of topical usefulness of latoconazole. The 1% solution or cream preparation of latoconazole was highly effective in both of the two tinea models and its 5 or more doses achieved almost complete mycological cure. However, both tinea models, especially the former, were considerably resistant to the therapeutic treatment of all of the reference drugs. These results suggest that latoconazole is a promising topical antifungal agent, probably applicable to the treatment of tinea pedis as well as other types of dermatomycoses.
AuthorsT Ohmi, S Konaka, M Uchida, H Yamaguchi
JournalArzneimittel-Forschung (Arzneimittelforschung) Vol. 41 Issue 8 Pg. 847-51 (Aug 1991) ISSN: 0004-4172 [Print] Germany
PMID1781809 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Antifungal Agents
  • Heterocyclic Compounds
  • Imidazoles
  • Tolnaftate
  • latoconazole
  • Clotrimazole
  • bifonazole
Topics
  • Animals
  • Antifungal Agents (therapeutic use)
  • Clotrimazole (therapeutic use)
  • Guinea Pigs
  • Heterocyclic Compounds (therapeutic use)
  • Imidazoles (therapeutic use)
  • Male
  • Microbial Sensitivity Tests
  • Tinea Pedis (drug therapy, microbiology)
  • Tolnaftate (therapeutic use)
  • Trichophyton (drug effects)

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