Influence of Anesthesia on Experimental Western Equine Encephalomyelitis.

Abstract

Anesthesia, by ether, is effective in the treatment of western equine encephalomyelitis in mice. Of mice treated with deep ether anesthesia soon after the intracerebral injection of western equine virus, only 58 per cent developed the disease as compared with 92.4 per cent of control animals. When anesthesia was delayed the approximate length of the incubation period, 60 per cent of the animals developed the disease as compared with 92.4 per cent of the controls. In addition, ether anesthesia delays the development of central nervous system symptoms not only when administered soon after the injection of the virus but also when administered after the disease has progressed far enough to cause objective signs of encephalitis.

• Authors: S E Sulkin, A Goth, C Zarafonetis
• Journal: Science (New York, N.Y.) (Science) Vol. 104 Issue 2690 Pg. 53-4 (Jul 19 1946) ISSN: 0036-8075 [Print] United States
• PMID: 17815490 (Publication Type: Journal Article)