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Tumor-associated trypsin inhibitor (TATI) in primary esophageal carcinoma.

Abstract
Esophageal carcinoma has a catastrophic clinical course with a very low 5 year survival rate of 5%. A circulating tumor marker with good specificity and sensitivity would be useful in the management strategy of the disease. So far, no tumor marker effective in esophageal carcinoma has been identified. Preliminary reports suggest satisfactory positivity rates of tumor-associated trypsin inhibitor (TATI) in esophageal carcinoma. We measured TATI levels in 71 patients with primary squamous cell esophageal carcinoma as well as in 30 tissue samples from both carcinoma and normal esophageal mucosa. Detectable TATI levels were not found in tumor tissue samples. The marker showed significantly higher serum levels in patients than in controls, with an overall positivity rate of 28%. TATI levels were significantly lower in patients with a high number of tumor-positive lymph nodes. No relationship was found between TATI and several other clinical and pathological parameters. High TATI levels correlated with a lower probability of overall survival as well as in cases without clinical evidence of lymph node metastases. TATI did not show any relationship with CEA, TPA, ferritin or SCC. The results of the present study suggest that TATI shows a satisfactory positivity rate in esophageal carcinoma, and TATI levels are related to local disease spread and prognosis.
AuthorsM Gion, R Mione, C Tremolada, P Dalla Palma, A Ruol, R Dittadi, A Leon, A Nosadini, C Castoro, G Bruscagnin
JournalScandinavian journal of clinical and laboratory investigation. Supplementum (Scand J Clin Lab Invest Suppl) Vol. 207 Pg. 37-41 ( 1991) ISSN: 0085-591X [Print] Norway
PMID1780688 (Publication Type: Journal Article)
Chemical References
  • Biomarkers, Tumor
  • Trypsin Inhibitor, Kazal Pancreatic
Topics
  • Biomarkers, Tumor (analysis, blood)
  • Carcinoma, Squamous Cell (chemistry, diagnosis)
  • Cytosol (chemistry)
  • Esophageal Neoplasms (chemistry, diagnosis)
  • Follow-Up Studies
  • Humans
  • Predictive Value of Tests
  • Prognosis
  • Trypsin Inhibitor, Kazal Pancreatic (analysis, blood)

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