[Study on the activity of acromegaly: evaluation of IGF-I].

Abstract

The evaluation of acromegaly only with GH levels can be difficult. We have evaluated in 32 acromegalic patients the clinical activity and baseline GH after oral glucose and THR. IGF-I was also evaluated. According GH suppression by glucose, three groups were established. A) minimum GH less than ng/ml, B) minimum GH 2-5 ng/ml and C) GH less than 2 ng/ml. IGF-1 in group A was 8.8 +/- 4.1 U/ml (mean +/- SD) and in group C IGF-I was 1.4 +/- 0.5 U/ml. Group B presented heterogeneous clinic and IGF-I levels. A 4 years clinical and hormonal follow-up could be performed in 20 patients. Those patients who were clinically inactive maintained their GH levels less than 2 ng/ml, with normal IGF-I titers throughout the follow-up period. In summary, IGF-I is very reliable in the evaluation of acromegaly activity and only requires a baseline determination being thus very useful in initial screening. It also determines with great reliability the treatment effectiveness in the evolutive study.

• Authors: J Larrañaga, E Carbó, C Horcajada, J L Herrera Pombo
• Journal: Revista clinica espanola (Rev Clin Esp) Vol. 188 Issue 3 Pg. 131-5 (Feb 1991) ISSN: 0014-2565 [Print] Spain
• Vernacular Title: Estudio sobre la actividad de la acromegalia: valoración del IGF-I.
• PMID: 1780511 (Publication Type: English Abstract, Journal Article)

Chemical References

• Insulin-Like Growth Factor I

Topics

• Acromegaly (blood)
• Adult
• Aged
• Female
• Humans
• Insulin-Like Growth Factor I (analysis)
• Male
• Middle Aged