Abstract | BACKGROUND:
Vitamin D3 is produced in the epidermis by ultraviolet (UV) radiation (290-315 nm) of 7-dehydrocholesterol. A similar range of 290-320 nm (broadband UVB) has been successfully used for years to treat psoriasis. The aim of this study was to investigate whether UVB therapy was able to influence vitamin D synthesis in psoriasis patients. METHODS: Twenty-four postmenopausal, white Caucasian women, aged 69 +/- 5.9 (mean +/- SD), with active plaque psoriasis, were treated with broadband UVB two to three times per week for 8-12 weeks. The serum concentrations of calcidiol (25( OH)D3), calcitriol ( 1,25(OH)2D3), intact parathyroid hormone (PTH), thyroid hormones, osteocalcin, calcium and creatinine were measured before the first and after the last dose of radiation. Bone density was measured using Dual-Energy X-ray Absorptiometry (Hologic Delphi A) at the hip and lumbar spine. RESULTS: CONCLUSION: UVB therapy in elderly psoriatic women improved psoriasis, increased serum 25( OH)D3 synthesis and reduced serum PTH concentrations.
|
Authors | Amra Osmancevic, Kerstin Landin-Wilhelmsen, Olle Larkö, Dan Mellström, Ann-Marie Wennberg, Lena Hulthén, Anne-Lene Krogstad |
Journal | Photodermatology, photoimmunology & photomedicine
(Photodermatol Photoimmunol Photomed)
Vol. 23
Issue 5
Pg. 172-8
(Oct 2007)
ISSN: 0905-4383 [Print] England |
PMID | 17803595
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Parathyroid Hormone
- Calcifediol
|
Topics |
- Aged
- Aged, 80 and over
- Anthropometry
- Body Mass Index
- Calcifediol
(biosynthesis)
- Female
- Humans
- Middle Aged
- Parathyroid Hormone
(metabolism)
- Phototherapy
- Postmenopause
- Psoriasis
(metabolism)
- Ultraviolet Rays
|