[Evaluation of the effectiveness of monotherapy in the treatment of epilepsy].

Abstract

On 44 patients undergoing monotherapy, with total plasma levels of drug therapeutic range, 33 had a reduction of the frequency of seizures, while the remaining 11 were unmodified. There was 90% improvement in Primary Generalized seizures, 73% in Secondary Generalized and 62% in Partial Complex; 27% of PC, 16% of PG and 16% of SG shifted to polytherapy. Considering that monotherapy can be better managed and is less toxic, we can recommend it as first choice treatment in newcomers, as a maintenance therapy, and as treatment of choice for the gradual elimination of therapy.

• Authors: F Brignolio, L Verzè, M Baruchello
• Journal: Minerva medica (Minerva Med) Vol. 82 Issue 12 Pg. 859-62 (Dec 1991) ISSN: 0026-4806 [Print] Italy
• Vernacular Title: Valutazione dell'efficacia della monoterapia nel trattamento dell'epilessia.
• PMID: 1780094 (Publication Type: English Abstract, Journal Article)

Chemical References

• Carbamazepine
• Valproic Acid
• Phenytoin
• Phenobarbital

Topics

• Adolescent
• Adult
• Aged
• Carbamazepine (therapeutic use)
• Child
• Drug Evaluation
• Epilepsy (drug therapy)
• Humans
• Middle Aged
• Phenobarbital (therapeutic use)
• Phenytoin (therapeutic use)
• Valproic Acid (therapeutic use)