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Hemoglobin Rainier (beta145 Tyrosine rarr Histidine): Alkali-Resistant Hemoglobin with Increased Oxygen Affinity.

Abstract
Hemoglobin Rainier, a new hemoglobin variant associated with erythrocytosis, was found in six members of a Caucasiant family. Structurally, it represents substitution of histidine for the invariant residute H23 tyrosine in the beta-hemoglobin polypeptide chain (beta(145) tyrosine --> histidine). Hemoglobin Rainier is the first example of a single amino acid substitution in adult human hemoglobin, causing increased resistance to alkali denaturation.
AuthorsG Stamatoyannopoulos, A Yoshida, J Adamson, S Heinenberg
JournalScience (New York, N.Y.) (Science) Vol. 159 Issue 3816 Pg. 741-3 (Feb 16 1968) ISSN: 0036-8075 [Print] United States
PMID17795074 (Publication Type: Journal Article)

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