Effects of topical application of UF-021, a novel prostaglandin derivative, on aqueous humor dynamics in normal human eyes.

Abstract

The mechanism underlying the intraocular pressure (IOP) lowering effect of a prostaglandin-related compound, isopropyl 20-ethyl-9 alpha,11 alpha-dihydroxy-15-keto-cis-delta 5-prostanoate (UF-021), and its possible adverse effects in long-term use were studied in normal human eyes. A single instillation of 0.12% UF-021 significantly lowered IOP without affecting aqueous flow rate, tonographic C value or episcleral venous pressure. Protein concentration in the anterior chamber and corneal endothelial permeability to fluorescein remained unaffected. It was suggested that UF-021 lowers IOP mainly by increasing uveoscleral outflow. Twice daily application of 0.12% UF-021 for 4 weeks caused no significant changes in aqueous protein concentration, aqueous flow rate or corneal endothelial permeability. Neither single nor long-term use of topical UF-021 induced irritative responses in the outer segment of the eye. The present study suggests that UF-021 has potential as a safe and effective ocular hypotensive drug with a mechanism of action different from other drugs currently available for the treatment of glaucoma.

• Authors: M Sakurai, M Araie, T Oshika, M Mori, K Masuda, R Ueno, M Takase
• Journal: Japanese journal of ophthalmology (Jpn J Ophthalmol) Vol. 35 Issue 2 Pg. 156-65 ( 1991) ISSN: 0021-5155 [Print] Japan
• PMID: 1779485 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Eye Proteins
• isopropyl unoprostone
• Dinoprost

Topics

• Administration, Topical
• Adult
• Anterior Chamber (metabolism)
• Aqueous Humor (chemistry, drug effects, metabolism)
• Dinoprost (analogs & derivatives, pharmacology)
• Endothelium, Corneal (metabolism)
• Eye Proteins (analysis)
• Fluorophotometry
• Humans
• Intraocular Pressure (drug effects)
• Permeability
• Pupil (drug effects)
• Random Allocation
• Sclera (blood supply)
• Tonometry, Ocular