[Seropositivity of anti-HTLV-II antibodies in patients with HTLV-I-associated myelopathy and adult T-cell leukemia].

Abstract

Dr Kira et al. (Lancet 1991, 338: 64-65) stress the high incidence of the co-infection with HTLV-I and HTLV-II in the HTLV-I associated myelopathy or tropical spastic paraparesis (HAM/TSP) detected by a polymerase chain reaction (PCR). They showed that 67% of HAM/TSP patients and 6% of healthy carriers had the co-infection. They suggested the co-infection might be important for the development of the myelopathy. Recently, we have analyzed the seropositivity of antibodies to HTLV-I and II in Adult T-cell Leukemia (ATL), HAM/TSP and carriers in Japan using SELECT-HTLV (IAF Biochem International Inc., Montreal, Canada). This system was a solid phase enzyme immunoassay utilizing synthetic peptides to differentiate between antibodies to type I and II. We examined 101 samples (31 ATL patients, 20 HAM/TSP and 50 carriers) which were all positive with the particle agglutination (PA, Fujirebio, Tokyo) and ELISA (Eisai, Tokyo). All samples were negative with HTLV-II and positive with HTLV-I. The results of our serological survey suggested that HTLV-II did not associate with the etiology of ATL and HAM/TSP in Japan.

• Authors: Y Nishimura, K Yoshiki, K Yamaguchi, T Kiyokawa, K Takatsuki
• Journal: Rinsho byori. The Japanese journal of clinical pathology (Rinsho Byori) Vol. 39 Issue 12 Pg. 1351-2 (Dec 1991) ISSN: 0047-1860 [Print] Japan
• PMID: 1779473 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• HTLV-II Antibodies

Topics

• HTLV-II Antibodies (analysis)
• HTLV-II Infections (complications, immunology)
• Humans
• Leukemia-Lymphoma, Adult T-Cell (complications, immunology)
• Paraparesis, Tropical Spastic (complications, immunology)