Abstract | PURPOSE: Chromosome 18q21 deletion and Smad4 protein inactivation have been reported as molecular markers predicting unfavorable outcome in colorectal cancers and, in a previous report, we recently revealed that these molecules are closely associated with distant metastasis, which is one of the clinical factors affecting postoperative survival. However, there has been no discussion as to how these molecules influence another clinical factor, namely, lymph node metastasis. In this report, we studied the significance of chromosome 18q deletion and loss of Smad4 protein expression in association with lymph node metastasis. METHOD: RESULTS: Immunohistochemical staining revealed that more cases showed a weaker stain for Smad4 protein in the lymph node positive group compared with the negative group (P = 0.00075). Furthermore, a higher ratio of 18q21 deletion was observed in the lymph node positive group (P = 0.029). CONCLUSION:
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Authors | Toshiaki Tanaka, Toshiaki Watanabe, Yoshihiro Kazama, Junichiro Tanaka, Takamitsu Kanazawa, Shinsuke Kazama, Hirokazu Nagawa |
Journal | Journal of surgical oncology
(J Surg Oncol)
Vol. 97
Issue 1
Pg. 69-73
(Jan 01 2008)
ISSN: 0022-4790 [Print] United States |
PMID | 17786972
(Publication Type: Journal Article)
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Copyright | (c) 2007 Wiley-Liss, Inc. |
Chemical References |
- SMAD4 protein, human
- Smad4 Protein
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Topics |
- Aged
- Chromosomes, Human, Pair 18
- Colorectal Neoplasms
(chemistry, genetics, pathology)
- Female
- Humans
- Immunohistochemistry
- Loss of Heterozygosity
- Lymphatic Metastasis
- Male
- Middle Aged
- Smad4 Protein
(analysis)
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