[Treatment of acute episodes of atopic dermatitis. Double-blind comparative study with 0.05% halometasone cream versus 0.25% prednicarbate cream].

Abstract

In a double-blind, randomized multicenter study in patients with acute episodes of atopic dermatitis, the efficacy and tolerance of 0.5% halometasone (Sicorten) cream were compared with those of 0.25% prednicarbate cream. A total of 165 patients (88 men, 77 women) were admitted to the study. The halometasone group contained 9% more cases with severe disease than did the prednicarbate group. Two daily nonocclusive applications were permitted, and treatment lasted 14 days. No difference in the onset of the effect was observed between the two groups. With respect to clinical efficacy, higher healing rates were found in the halometasone group: 50.6% versus 34.5% in the patients as a whole, and 39.5% vs. 16.2% in the subgroup of clinically severe cases. Applying stratification, a statistical difference was found in the clinically severe cases. Both creams were well tolerated; undesired side effects were observed neither with halometasone cream nor with prednicarbate cream. Cosmetic acceptance was assessed as very good by 50.6% of patients treated with halometasone cream, and 46.0% of patients treated with prednicarbate cream. Summarizing, it may be noted that halometasone cream is more effective than prednicarbate cream, and is equally well tolerated.

• Authors: R Ulrich, I Andresen
• Journal: Fortschritte der Medizin (Fortschr Med) Vol. 109 Issue 36 Pg. 741-4 (Dec 20 1991) ISSN: 0015-8178 [Print] Germany
• Vernacular Title: Behandlung akuter Schübe der atopischen Dermatitis. Doppelblinde Vergleichsstudie mit 0.05%-Halometason-Creme versus 0.25%-Prednicarbat-Creme.
• PMID: 1778534 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)

Chemical References

• Anti-Inflammatory Agents
• Ointments
• Betamethasone
• Prednisolone
• halometasone
• prednicarbate

Topics

• Acute Disease
• Administration, Topical
• Adolescent
• Adult
• Anti-Inflammatory Agents (therapeutic use)
• Betamethasone (administration & dosage, analogs & derivatives, therapeutic use)
• Child
• Child, Preschool
• Dermatitis, Atopic (drug therapy)
• Double-Blind Method
• Female
• Humans
• Infant
• Male
• Middle Aged
• Ointments
• Prednisolone (administration & dosage, analogs & derivatives, therapeutic use)