Effect of medium- and long-chain triglyceride infusion on lipoprotein and hepatic lipase in healthy subjects.

Abstract

Plasma lipolytic activity and hydrolysis of intravenous fat were studied in six healthy subjects during infusion of a long-chain triglyceride (LCT) fat emulsion (Intralipid 20%) or of a medium-chain triglyceride (MCT)/LCT emulsion (Lipofundin MCT 20%). The fat emulsions were infused continuously at a rate of 0.17 g triglyceride kg-1 body weight (BW)h-1 for 6 h in random order at 7-day intervals. A continuous infusion of glucose (0.18 g kg-1 BW h-1) was administered for a period of 7 h and was started 1 h before the lipid infusion. Infusions of both types of fat increased plasma triglyceride (TG), free fatty acid (FFA) and lipoprotein lipase (LPL) levels and steady-state values were present during the 3rd to 5th h of infusion. MCT/LCT infusion resulted in higher plasma levels at steady-state of TG (3.63 +/- 0.45 [SEM] vs 2.73 +/- 0.45 mmol l-1; P less than 0.05), FFA (1.05 +/- 0.08 vs 0.54 +/- 0.04 mmol l-1; P less than 0.01) and LPL (4.6 +/- 0.6 vs 2.6 +/- 0.5 mU ml-1; P less than 0.05) in comparison with LCT administration. There was a positive correlation between plasma LPL activity and TG concentration (r = 0.77; P less than 0.001) when data for the two infusions were combined. Although the same amount of fat was infused on a weight basis, the molar infusion rate was 40% higher with MCT/LCT than with LCT infusion, due to differences in molecular weights (634 vs 885 Da).(ABSTRACT TRUNCATED AT 250 WORDS)

• Authors: J Nordenström, G Neeser, T Olivecrona, J Wahren
• Journal: European journal of clinical investigation (Eur J Clin Invest) Vol. 21 Issue 6 Pg. 580-5 (Dec 1991) ISSN: 0014-2972 [Print] England
• PMID: 1778219 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Drug Combinations
• Fat Emulsions, Intravenous
• Fatty Acids, Nonesterified
• Phospholipids
• Triglycerides
• Lipofundin
• Sorbitol
• Lipase
• Lipoprotein Lipase

Topics

• Adult
• Drug Combinations
• Fat Emulsions, Intravenous (pharmacology)
• Fatty Acids, Nonesterified (blood)
• Humans
• Lipase (metabolism)
• Lipolysis (drug effects)
• Lipoprotein Lipase (blood)
• Liver (drug effects, enzymology)
• Male
• Phospholipids (pharmacology)
• Sorbitol (pharmacology)
• Triglycerides (blood, chemistry, pharmacology)