| Abstract | It was found that intoxication of animals with aminobiphenyls leads to the activation of such glutathione-dependent enzymes as glutathione-S-transferase and glutathione reductase. This is accompanied by the induction of activities of individual isoforms of the multifunctional family of glutathione-S-transferases. There was a decrease in the glutathione peroxidase activity after intoxication with benzidine derivatives. It was found that the GSH content in rat liver decreased after benzidine intoxication and sharply increased after effects of 3,3'-dimethylbenzidine and 3,3'-dimethoxybenzidine. In all cases studied there was a diminution in the level of diene conjugates. It was supposed that the specificity of the catalytic glutathione redox system reaction is due to structural peculiarities of the aminobiphenyls being injected. Analysis of functional pairs of glutathione-dependent enzymes revealed a certain imbalance in the antioxidant system function after aminobiphenyl poisoning. |
| Authors | T G Semak, V P Kurchenko, A T Pikulev |
| Journal | Biokhimii͡a (Moscow, Russia)
(Biokhimiia)
Vol. 56
Issue 10
Pg. 1806-11
(Oct 1991)
ISSN: 0320-9725 USSR |
| Vernacular Title | Sostoianie antioksidantnoĭ sistemy i perekisnogo okisleniia lipidov v pecheni krys posle intoksikatsii zhivotnykh aminobifenilami. |
| PMID | 1777520
(Publication Type: English Abstract, Journal Article)
|
| Chemical References |
- Aminobiphenyl Compounds
- Antioxidants
- Benzidines
- Carcinogens
- Dianisidine
- 2-tolidine
- Glutathione Reductase
- Glutathione Transferase
|
| Topics |
- Aminobiphenyl Compounds
(poisoning)
- Animals
- Antioxidants
- Benzidines
- Carcinogens
- Dianisidine
(poisoning)
- Glutathione Reductase
(metabolism)
- Glutathione Transferase
(metabolism)
- Lipid Peroxidation
- Liver
(drug effects, enzymology, metabolism)
- Male
- Oxidation-Reduction
- Rats
|
