Vascular endothelial growth factor promoted endothelial progenitor cell mobilization into the peripheral blood of a patient with POEMS syndrome.

Abstract

We assessed the percentage of endothelial progenitor cells (EPCs) in the peripheral blood of a patient with POEMS with elevated VEGF plasma levels. High VEGF plasma levels were associated with increased EPC concentration and treatment with an anti-VEGF antibody induced a consensual decrease of both parameters. In vitro cultures of the patient BM cells suggested that the stromal compartment could be responsible for VEGF overproduction.

• Authors: Vittorio Rosti, Margherita Massa, Rita Campanelli, Mara De Amici, Giovanni Piccolo, Vittorio Perfetti
• Journal: Haematologica (Haematologica) Vol. 92 Issue 9 Pg. 1291-2 (Sep 2007) ISSN: 1592-8721 [Electronic] Italy
• PMID: 17768134 (Publication Type: Letter)

Chemical References

• Angiogenesis Inhibitors
• Antibodies, Monoclonal
• Antibodies, Monoclonal, Humanized
• VEGFA protein, human
• Vascular Endothelial Growth Factor A
• Bevacizumab

Topics

• Angiogenesis Inhibitors (therapeutic use)
• Antibodies, Monoclonal (therapeutic use)
• Antibodies, Monoclonal, Humanized
• Bevacizumab
• Cell Movement
• Cells, Cultured
• Endothelium, Vascular (cytology, metabolism)
• Humans
• Neovascularization, Pathologic
• POEMS Syndrome (blood, drug therapy, pathology)
• Stem Cells (cytology, metabolism)
• Vascular Endothelial Growth Factor A (pharmacology)