[The diagnosis and monitoring of transitional cell cancer of the urinary tract through nuclear matrix protein 22].

Abstract

OBJECTIVE:

To evaluate the urinary nuclear matrix protein (NMP22) as an adjuvant diagnostic index for transitional cell carcinoma of urinary tract and monitoring the state of disease.

METHODS:

Urinary samples were collected from 262 patients with transitional cell carcinoma, 198 non-transitional cell carcinoma of the urinary tract and 65 patients with benign diseases. Urinary NMP22 concentration was determined through enzyme linked immunosorbent assay (ELISA).

RESULTS:

The urinary NMP22 concentration had significant difference among the three groups (Kruskal Wallis, chi(2) = 197.17 P < 0.001). The detection sensitivity and specificity of urinary NMP22 to transitional cell carcinoma were 71.37% and 87.69% respectively. The NMP22 concentration showed significant difference among three groups divided according to the pathological grade (Kruskal-Wallis test, chi(2) = 34.06 P < 0.01). The NMP22 concentration was significant lower in the recovery patients after the operation than the peoples of pre-operation and recurrence (Kruskal-Wallis test, chi(2) = 37.53, P < 0.001).

CONCLUSION:

MP22 is a helpful tumor marker for the diagnosis of transitional cell carcinoma and monitoring the state of illness with increased efficacy.

• Authors: Hui-Qing Chen, Cun-Zhi Han, Li-Li Du, Yu Cui, Dong-Zhi Pang, Jie-Xian Jing, Xian-Wen Zhao, Bao-Guo Tian, Zhen-Guo Mi
• Journal: Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] (Zhonghua Yu Fang Yi Xue Za Zhi) Vol. 41 Suppl Pg. 84-6 (Jun 2007) ISSN: 0253-9624 [Print] China
• PMID: 17767866 (Publication Type: English Abstract, Journal Article)

Chemical References

• Biomarkers, Tumor
• Nuclear Proteins
• nuclear matrix protein 22

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Biomarkers, Tumor (urine)
• Carcinoma, Transitional Cell (diagnosis, urine)
• Child
• Female
• Humans
• Male
• Middle Aged
• Nuclear Proteins (urine)
• Urinary Bladder Neoplasms (diagnosis, urine)