Dehydroxymethylepoxyquinomicin (DHMEQ) therapy reduces tumor formation in mice inoculated with tax-deficient adult T-cell leukemia-derived cell lines.

Abstract

Adult T-cell leukemia (ATL) is an aggressive neoplasm caused by human T-cell leukemia virus type I (HTLV-I), which induces nuclear factor-kappaB (NF-kappaB), a molecule central to the ensuing neoplasia. The NF-kappaB inhibitor dehydroxymethylepoxyquinomicin (DHMEQ) has been shown to inhibit NF-kappaB activation in Tax-expressing HTLV-I-infected cells. In this study, we used NOD/SCID beta2-microglobulin(null) mice to show that intraperitoneal inoculation with Tax-deficient ATL cell lines caused rapid death, whereas DHMEQ-treated mice survived. Furthermore, DHMEQ treatment after subcutaneous inoculation inhibited the growth of transplanted ATL cells. These results demonstrate that DHMEQ has therapeutic efficacy on ATL cells, regardless of Tax expression.

• Authors: Takeo Ohsugi, Toshio Kumasaka, Seiji Okada, Takaomi Ishida, Kazunari Yamaguchi, Ryouichi Horie, Toshiki Watanabe, Kazuo Umezawa
• Journal: Cancer letters (Cancer Lett) Vol. 257 Issue 2 Pg. 206-15 (Nov 18 2007) ISSN: 0304-3835 [Print] Ireland
• PMID: 17764832 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Benzamides
• Cyclohexanones
• Gene Products, tax
• NF-kappa B
• RNA, Messenger
• beta 2-Microglobulin
• dehydroxymethylepoxyquinomicin

Topics

• Adult
• Animals
• Apoptosis (drug effects)
• Benzamides (pharmacology, therapeutic use)
• Cell Line, Tumor
• Cyclohexanones (pharmacology, therapeutic use)
• Gene Products, tax (deficiency, genetics)
• Human T-lymphotropic virus 1 (genetics, metabolism)
• Humans
• Leukemia, T-Cell (pathology, prevention & control, virology)
• Mice
• Mice, Inbred NOD
• Mice, Knockout
• Mice, SCID
• NF-kappa B (antagonists & inhibitors, metabolism)
• RNA, Messenger (genetics, metabolism)
• Reverse Transcriptase Polymerase Chain Reaction
• Survival Analysis
• Tumor Burden
• Xenograft Model Antitumor Assays (methods)
• beta 2-Microglobulin (genetics, metabolism)