[Electrophysiological anti-arrhythmia effects of tiracizine in ventricular tachycardia].

Abstract

The electrophysiologic effects and antiarrhythmic efficacy of tiracizine, a new class I antiarrhythmic drug, were studied in 16 patients with documented sustained ventricular tachycardia (VT) after intravenous drug application and in 6 patients after oral drug administration by means of programmed ventricular stimulation (PVS). After intravenous tiracizine (0.3 mg/kg) the VT was no longer inducible by PVS in 3 of 16 patients and became nonsustained in another patient. In 11 of 13 patients with further inducible VT the cycle duration of VT increased after tiracizine (mean 29 ms). After oral tiracizine (150-225 mg/day) the VT induction was suppressed in one patient. In a second patient the VT became nonsustained. Cycle length of VT in 4 patients with persistent induction of VT was longer after therapy (mean 88 ms). Antiarrhythmic efficacy of intravenous or oral tiracizine can be expected in at least one third of patients with VT.

• Authors: H Volkmann, H Kühnert, G Dannberg, M Heinke, U Leeder, U Popp
• Journal: Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete (Z Gesamte Inn Med) Vol. 46 Issue 17 Pg. 635-41 (Dec 1991) ISSN: 0044-2542 [Print] Germany
• Vernacular Title: Elektrophysiologische und antiarrhythmische Effekte von Tiracizin bei ventrikulären Tachykardien.
• PMID: 1776306 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anti-Arrhythmia Agents
• Dibenzazepines
• tiracizine

Topics

• Administration, Oral
• Adult
• Aged
• Anti-Arrhythmia Agents (therapeutic use)
• Dibenzazepines (administration & dosage, pharmacology, therapeutic use)
• Electric Stimulation
• Electrocardiography
• Female
• Heart Conduction System (drug effects)
• Heart Ventricles (drug effects)
• Humans
• Injections, Intravenous
• Male
• Middle Aged
• Tachycardia (drug therapy, physiopathology)