Anxiolytic-like and antidepressant-like effects produced by the selective 5-HT6 receptor antagonist SB-258585 after intrahippocampal administration to rats.

Abstract	The purpose of this study was to investigate the effect of SB-258585, a selective 5-HT6 receptor antagonist, administered intrahippocampally to rats, in the conflict drinking and forced swim tests, that is models used for evaluating anxiolytic-like and antidepressant-like activity, respectively. Diazepam and imipramine were used as reference drugs. SB-258585 at a dose of 1 microg (but not 0.3 and 3 microg) showed an anticonflict effect that was weaker than that of diazepam (40 microg). SB-258585 at a dose of 3 microg (but not 1 and 10 microg) produced a marked anti-immobility effect comparable with that of imipramine (0.1 microg). The anxiolytic-like and antidepressant-like activity of SB-258585 seemed to be specific, as that compound--when given by the same route in doses effective in each model--did not affect the shock threshold, nonpunished water consumption, or exploratory activity of rats. The results obtained indicate that the hippocampus is one of the neuroanatomical sites involved in the anxiolytic-like and antidepressant-like activity of the selective 5-HT6 receptor antagonist SB-258585.
Authors	Anna Wesołowska, Agnieszka Nikiforuk, Katarzyna Stachowicz
Journal	Behavioural pharmacology (Behav Pharmacol) Vol. 18 Issue 5-6 Pg. 439-46 (Sep 2007) ISSN: 0955-8810 [Print] England
PMID	17762512 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Anti-Anxiety Agents Antidepressive Agents Piperazines Receptors, Serotonin SB 258585 Serotonin Antagonists Sulfonamides serotonin 6 receptor Imipramine Diazepam
Topics	Animals Anti-Anxiety Agents (administration & dosage, pharmacology) Antidepressive Agents (administration & dosage, pharmacology) Anxiety (drug therapy) Depression (drug therapy) Diazepam (pharmacology) Disease Models, Animal Dose-Response Relationship, Drug Drinking Behavior (drug effects) Exploratory Behavior (drug effects) Hippocampus (drug effects, metabolism) Imipramine (pharmacology) Male Piperazines (administration & dosage, pharmacology) Rats Rats, Wistar Receptors, Serotonin (drug effects) Serotonin Antagonists (administration & dosage, pharmacology) Sulfonamides (administration & dosage, pharmacology) Swimming

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