Abstract | OBJECTIVES: METHODS: Patients with adenocarcinoma of the rectum stage >or=T3 or >or=N1 were treated with capecitabine 1330 mg/m per day in 2 divided doses days 1 to 42 and 50.4 Gy of RT in 28 1.8-Gy fractions. Patients with metastatic disease were eligible provided that operative intervention on primary site was anticipated. Surgery resection occurred 4 to 6 weeks after completion of preoperative therapy. RESULTS: Thirty eligible patients were enrolled at two institutions. Median age and performance status were 62 years and 90%, respectively. Twenty-eight patients (93%) completed combined modality therapy and 27 underwent resection, including 17 abdominal-perineal and 9 low anterior resections. Three of 27 (11%) had pathologic complete response (pCR) with an additional 7 (26%) having minimal residual disease. Two patients who were felt to require abdominal perineal resection prior to combined modality therapy (CMT) were able to have sphincter-sparing surgery. No patients had progression during CMT which precluded surgical resection. Treatment was well tolerated with >or=grade 3 toxicities limited to diarrhea (5 patients), hand-foot syndrome (1 patient), dermatitis (1 patient). Twenty-four patients are living, 18 with no evidence of disease. CONCLUSIONS: The combination of preoperative capecitabine and RT in patients with LARC has significant antitumor activity, efficacy, and a low toxicity profile.
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Authors | Sameer P Desai, Basil F El-Rayes, Edgar Ben-Josef, Joel K Greenson, James A Knol, Emina H Huang, Kent A Griffith, Philip A Philip, Cornelius J McGinn, Mark M Zalupski |
Journal | American journal of clinical oncology
(Am J Clin Oncol)
Vol. 30
Issue 4
Pg. 340-5
(Aug 2007)
ISSN: 1537-453X [Electronic] United States |
PMID | 17762432
(Publication Type: Clinical Trial, Phase II, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antimetabolites, Antineoplastic
- Deoxycytidine
- Capecitabine
- Fluorouracil
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Topics |
- Adenocarcinoma
(drug therapy, radiotherapy, secondary)
- Adult
- Aged
- Aged, 80 and over
- Antimetabolites, Antineoplastic
(therapeutic use)
- Capecitabine
- Combined Modality Therapy
- Deoxycytidine
(analogs & derivatives, therapeutic use)
- Disease-Free Survival
- Female
- Fluorouracil
(analogs & derivatives, therapeutic use)
- Humans
- Liver Neoplasms
(secondary)
- Lung Neoplasms
(secondary)
- Male
- Middle Aged
- Preoperative Care
- Rectal Neoplasms
(drug therapy, pathology, radiotherapy)
- Treatment Outcome
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