Maintenance therapy involving a tapering dose of danazol or mid/low doses of oral contraceptive after gonadotropin-releasing hormone agonist treatment for endometriosis-associated pelvic pain.

Abstract

Pelvic pain associated with endometriosis was treated by the long-term administration of a tapering dose of danazol or mid/low doses of oral contraceptives after the end of therapy involving a GnRH agonist (GnRH-a). Results demonstrated that each of these three therapies is a practical and efficient treatment regimen to maintain the relief of pelvic pain achieved by GnRH-a therapy, at least for a period of 12 months.

• Authors: Jo Kitawaki, Hiroaki Ishihara, Miyo Kiyomizu, Hideo Honjo
• Journal: Fertility and sterility (Fertil Steril) Vol. 89 Issue 6 Pg. 1831-5 (Jun 2008) ISSN: 1556-5653 [Electronic] United States
• PMID: 17761178 (Publication Type: Journal Article)

Chemical References

• CA-125 Antigen
• Contraceptives, Oral
• Estrogen Antagonists
• Gonadotropin-Releasing Hormone
• Danazol

Topics

• CA-125 Antigen (blood)
• Contraceptives, Oral (therapeutic use)
• Danazol (therapeutic use)
• Dysmenorrhea (prevention & control)
• Endometriosis (complications, pathology)
• Estrogen Antagonists (therapeutic use)
• Female
• Gonadotropin-Releasing Hormone (agonists)
• Humans
• Pelvic Pain (drug therapy, etiology)