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[Clinical characteristics and chemotherapy of advanced-stage bronchioloalveolar carcinoma of the lung: report of 53 patients].

AbstractOBJECTIVE:
To analyze the clinical feature and the value of chemotherapy for advanced stage bronchioloalveolar carcinoma (BAC) of the lung.
METHODS:
The clinical data of 53 advanced stage BAC patients treated from Jan. 1999 to Dec. 2004 was collected and reviewed. Most of the patients received more than 2 cycles of the combined chemotherapy with platinum-based regimen.
RESULTS:
Of these 53 eligible patients in this series, 34 (64.2%) were women, 42 (79.2%) never smoked any cigarette, 29 (54.7%) originated from the right lung, and 12 patients (22.6%) showed bilateral multi-lobular or multi-central lesions or diffusive pulmonary involvement. The objective response rate was 17.0% (2 complete response, 7 partial response). 30 (56.6%) patients demonstrated stable disease and 14 (26.4%) patients showed progression of the disease. The median progression-free and overall survivals were 6.1 and 16.0 months, respectively. The 1-year survival rate was 71.7%. Grade 3 or severer toxicities included neutropenia (34.0%), thrombocytopenia (15.1%), anemia (22.6%), nausea and vomiting (39.6%), alopecia (30.2%), constipation (17.0%) and peripheral neurotoxicity (13.2%).
CONCLUSION:
Advanced bronchioloalveolar carcinoma is likely to occur in woman, nonsmoker and the right lung, frequently with bilateral diffuse pulmonary involvement. The platinum-based combined chemotherapy regimen is modestly effective with tolerable toxicity. Compared with the historical data of lung adenocarcinoma of the same stage, bronchioloalveolar carcinoma has a longer overall survived.
AuthorsYong Li, Xiang-ru Zhang, Yan Sun
JournalZhonghua zhong liu za zhi [Chinese journal of oncology] (Zhonghua Zhong Liu Za Zhi) Vol. 29 Issue 4 Pg. 298-301 (Apr 2007) ISSN: 0253-3766 [Print] China
PMID17760260 (Publication Type: Journal Article)
Chemical References
  • Deoxycytidine
  • Vinblastine
  • Cisplatin
  • Vinorelbine
  • Gemcitabine
Topics
  • Adenocarcinoma, Bronchiolo-Alveolar (drug therapy, pathology)
  • Adult
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
  • Cisplatin (administration & dosage)
  • Deoxycytidine (administration & dosage, analogs & derivatives)
  • Disease-Free Survival
  • Female
  • Follow-Up Studies
  • Humans
  • Lung Neoplasms (drug therapy, pathology)
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Neutropenia (chemically induced)
  • Remission Induction
  • Retrospective Studies
  • Sex Factors
  • Smoking
  • Vinblastine (administration & dosage, analogs & derivatives)
  • Vinorelbine
  • Gemcitabine

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