Pretreatment with topical nonsteroidal anti-inflammatory drugs is common practice to maintain maximal pupil dilation for
cataract surgery. Most surgeons also inject a
cholinergic agent intracamerally for
miosis after
intraocular lens insertion. We evaluated the effects of topical
suprofen and
flurbiprofen on the
miosis induced by anterior chamber irrigation with either
acetylcholine or
carbachol. One eye of 30 pigmented rabbits was dilated with
cyclopentolate HCl and
phenylephrine HCl. Three groups, each composed of ten eyes, received
flurbiprofen,
suprofen, or a control. In each group, five eyes received
acetylcholine by anterior chamber irrigation and five received
carbachol. Pupil diameters were measured with calipers before and five minutes after irrigation by an observer unaware of the treatment regimen. Irides irrigated with
carbachol constricted less than those irrigated with
acetylcholine (P = .016). In anterior chambers irrigated with
carbachol,
suprofen was associated with less
miosis than either tears (P = .005) or
flurbiprofen (P = .009); however, if the infusion was performed with
acetylcholine, no differences between the three groups were noted (P = .44).