Effects of prostaglandin antagonism on sodium arachidonate fever in rabbits.

Abstract

1. Sodium arachidonate, the prostaglandin precursor substance, when injected intraventricularly into rabbits, results in dose-dependent hyperthermia, which is rapid in onset and of several hours duration. 2. Arachidonate fever was inhibited by intraventricular injection of indomethacin, but not by the simultaneous intraventricular injection of either of the two prostaglandin antagonists SC 19220 or HR 546. 3. Both antagonists effectively inhibited the fever induced by the intraventricular injection of an equipotent dose of PGE1. 4. Our results show that a derivative of arachidonic acid other than prostaglandin is pyrogenic.

• Authors: H Laburn, D Mitchell, C Rosendorff
• Journal: The Journal of physiology (J Physiol) Vol. 267 Issue 2 Pg. 559-70 (May 1977) ISSN: 0022-3751 [Print] England
• PMID: 17735 (Publication Type: Journal Article)

Chemical References

• Arachidonic Acids
• Prostaglandin Antagonists
• Prostaglandins A
• Prostaglandins E
• Prostaglandins, Synthetic
• Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide
• Indomethacin

Topics

• Animals
• Arachidonic Acids (antagonists & inhibitors, pharmacology)
• Body Temperature (drug effects)
• Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide (pharmacology)
• Fever (chemically induced)
• Indomethacin (pharmacology)
• Injections, Intraventricular
• Prostaglandin Antagonists (pharmacology)
• Prostaglandins A (pharmacology)
• Prostaglandins E (adverse effects)
• Prostaglandins, Synthetic (pharmacology)
• Rabbits