Abstract |
T lymphocytes recognize antigen associated with MHC class I and/or class II gene products. Recognition of malignant cells is therefore dependent on presentation of tumor associated antigen(s) by MHC molecules. We have studied immunity to tumors that have down-regulated class I expression. These studies demonstrate a requirement for class I antigens, but suggest that additional factors may also be required for tumor-specific immunity. The MHC also encodes TLA class I antigens, whose function is unknown. Our studies suggest that these molecules function is unknown. Our studies suggest that T lymphocytes, specifically in tumor cells that do not express H-2K or H-2D moieties. Other studies are aimed at improving tumor-specific Th cell generation by producing class II+ tumor cells. The success of these experiments indicates that this approach may be a potentially useful immunotherapy.
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Authors | S Ostrand-Rosenberg, E P Garcia, C A Roby, V K Clements |
Journal | Seminars in cancer biology
(Semin Cancer Biol)
Vol. 2
Issue 5
Pg. 311-9
(Oct 1991)
ISSN: 1044-579X [Print] England |
PMID | 1773047
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S., Review)
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Chemical References |
- Antigens, Neoplasm
- H-2 Antigens
- Histocompatibility Antigens Class I
- Histocompatibility Antigens Class II
- Peptide Fragments
- Q surface antigens
- Receptors, Antigen, T-Cell
- Tla antigens
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Topics |
- Animals
- Antigens, Neoplasm
(immunology)
- Genes, MHC Class I
- Genes, MHC Class II
- H-2 Antigens
(genetics, immunology)
- Histocompatibility Antigens Class I
(genetics, immunology)
- Histocompatibility Antigens Class II
(genetics, immunology)
- Humans
- Immunologic Surveillance
- Mice
- Mice, Inbred Strains
(genetics, immunology)
- Neoplasms
(genetics, immunology)
- Peptide Fragments
(immunology)
- Receptors, Antigen, T-Cell
(immunology)
- Sarcoma
(genetics, immunology)
- Teratoma
(genetics, immunology)
- Transfection
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