Influence of major histocompatibility complex class I, class II and TLA genes on tumor rejection.

T lymphocytes recognize antigen associated with MHC class I and/or class II gene products. Recognition of malignant cells is therefore dependent on presentation of tumor associated antigen(s) by MHC molecules. We have studied immunity to tumors that have down-regulated class I expression. These studies demonstrate a requirement for class I antigens, but suggest that additional factors may also be required for tumor-specific immunity. The MHC also encodes TLA class I antigens, whose function is unknown. Our studies suggest that these molecules function is unknown. Our studies suggest that T lymphocytes, specifically in tumor cells that do not express H-2K or H-2D moieties. Other studies are aimed at improving tumor-specific Th cell generation by producing class II+ tumor cells. The success of these experiments indicates that this approach may be a potentially useful immunotherapy.
AuthorsS Ostrand-Rosenberg, E P Garcia, C A Roby, V K Clements
JournalSeminars in cancer biology (Semin Cancer Biol) Vol. 2 Issue 5 Pg. 311-9 (Oct 1991) ISSN: 1044-579X [Print] UNITED STATES
PMID1773047 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S., Review)
Chemical References
  • Antigens, Neoplasm
  • H-2 Antigens
  • Histocompatibility Antigens Class I
  • Histocompatibility Antigens Class II
  • Peptide Fragments
  • Q surface antigens
  • Receptors, Antigen, T-Cell
  • Tla antigens
  • Animals
  • Antigens, Neoplasm (immunology)
  • Genes, MHC Class I
  • Genes, MHC Class II
  • H-2 Antigens (genetics, immunology)
  • Histocompatibility Antigens Class I (genetics, immunology)
  • Histocompatibility Antigens Class II (genetics, immunology)
  • Humans
  • Immunologic Surveillance
  • Mice
  • Mice, Inbred Strains (genetics, immunology)
  • Neoplasms (genetics, immunology)
  • Peptide Fragments (immunology)
  • Receptors, Antigen, T-Cell (immunology)
  • Sarcoma (genetics, immunology)
  • Teratoma (genetics, immunology)
  • Transfection

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