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Changes in urinary dinor dihydro F(2)-isoprostane metabolite concentrations, a marker of oxidative stress, during and following asthma exacerbations.

Abstract
To investigate changes in oxidant stress during and following acute asthma exacerbations, this study measured 2,3-dinor-5,6-dihydro-15-F(2t)-IsoP (F(2)-IsoP-M), the major urinary metabolite of 15-F(2t)-IsoP, in eight asthmatic adults, during and following an asthma hospitalization. F(2)-IsoP-M concentrations at admission and follow-up were significantly higher than discharge (admission median: 4.12 ng/Cr mg, range 1.89-7.8; follow-up: 2.47 ng/Cr mg (1.56-6.86); discharge: 1.42 ng/Cr mg (0.7-4.44); both p<0.01), but not significantly different between admission and follow-up. F(2)-IsoP-M concentrations at follow-up were higher than a control group with stable asthma (0.68 ng/Cr mg (0.31-1.5), p=0.0008). In conclusion, asthma exacerbations requiring hospitalization are associated with 6-fold higher urinary F(2)-IsoP-M concentrations compared to stable asthmatics. F(2)-IsoP-M concentrations decreased significantly during hospitalization, but significant elevations 3 months following hospitalization suggest ongoing oxidative stress despite clinical improvement. Urinary F(2)-IsoP-M may be a clinically useful, simple non-invasive systemic measure of oxidative stress in asthmatics, providing information not captured by spirometry or symptoms.
AuthorsPingsheng Wu, Lyman J Roberts 2nd, Ayumi K Shintani, James R Sheller, Patricia A Minton, Stanley B Higgins, Tina V Hartert
JournalFree radical research (Free Radic Res) Vol. 41 Issue 9 Pg. 956-62 (Sep 2007) ISSN: 1071-5762 [Print] England
PMID17729112 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
Chemical References
  • 2,3-dinor-5,6-dihydro-15-F-isoprostane
  • Biomarkers
  • 8-epi-prostaglandin F2alpha
  • Dinoprost
Topics
  • Adult
  • Asthma (diagnosis)
  • Biomarkers (urine)
  • Case-Control Studies
  • Dinoprost (analogs & derivatives, metabolism, urine)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Oxidative Stress

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