| Abstract | To investigate changes in oxidant stress during and following acute asthma exacerbations, this study measured 2,3-dinor-5,6-dihydro-15-F(2t)-IsoP (F(2)-IsoP-M), the major urinary metabolite of 15-F(2t)-IsoP, in eight asthmatic adults, during and following an asthma hospitalization. F(2)-IsoP-M concentrations at admission and follow-up were significantly higher than discharge (admission median: 4.12 ng/Cr mg, range 1.89-7.8; follow-up: 2.47 ng/Cr mg (1.56-6.86); discharge: 1.42 ng/Cr mg (0.7-4.44); both p<0.01), but not significantly different between admission and follow-up. F(2)-IsoP-M concentrations at follow-up were higher than a control group with stable asthma (0.68 ng/Cr mg (0.31-1.5), p=0.0008). In conclusion, asthma exacerbations requiring hospitalization are associated with 6-fold higher urinary F(2)-IsoP-M concentrations compared to stable asthmatics. F(2)-IsoP-M concentrations decreased significantly during hospitalization, but significant elevations 3 months following hospitalization suggest ongoing oxidative stress despite clinical improvement. Urinary F(2)-IsoP-M may be a clinically useful, simple non-invasive systemic measure of oxidative stress in asthmatics, providing information not captured by spirometry or symptoms. |
| Authors | Pingsheng Wu, Lyman J Roberts 2nd, Ayumi K Shintani, James R Sheller, Patricia A Minton, Stanley B Higgins, Tina V Hartert
(Affiliation: Department of Medicine and the Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.)
|
| Journal | Free radical research
(Free Radic Res)
Vol. 41
Issue 9
Pg. 956-62
(Sep 2007)
ISSN: 1071-5762 England |
| PMID | 17729112
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- 2,3-dinor-5,6-dihydro-15-F-isoprostane
- Biological Markers
- 8-epi-prostaglandin F2alpha
- Dinoprost
|
| Topics |
- Adult
- Asthma
(diagnosis)
- Biological Markers
(urine)
- Case-Control Studies
- Dinoprost
(analogs & derivatives, metabolism, urine)
- Female
- Humans
- Male
- Middle Aged
- Oxidative Stress
|
