| Abstract | BACKGROUND: Tourette syndrome is a neuropsychiatric disorder characterized by motor and vocal tics, attentional deficit, poor control of impulses and obsessive compulsive disorder. Pharmacological treatment is often disappointing due to partial response and frequent poor tolerance to neuroleptic drugs which are otherwise the most effective therapy so far. AIM: To report a lasting improvement obtained with a new drug, aripiprazole that acts modulating both dopaminergic and serotoninergic neurotransmission. MATERIAL AND METHODS: Ten patients refractory to their usual therapy, aged 10 to 35 years, were switched to aripiprazole in an open trial. RESULTS: Nine of the 10 patients showed a significant response assessed by the Yale severity tics rating scale and the clinical global impression scale (p <0.01). No relevant adverse effects were observed. CONCLUSIONS: Aripiprazole may be a good pharmacological option for patients with Tourette syndrome. |
| Authors | Marcelo Miranda C, Claudia Castiglioni T
(Affiliation: Unidad de Neurología, Clínica Las Condes. Fundación Parkinson y Alzheimer. marcelomirandac at gmail.com)
|
| Journal | Revista médica de Chile
(Rev Med Chil)
Vol. 135
Issue 6
Pg. 773-6
(Jun 2007)
ISSN: 0034-9887 Chile |
| Vernacular Title | Aripiprazole en el tratamiento sintomático del síndrome de Gilíes de la Tourette (enfermedad de los tics). |
| PMID | 17728905
(Publication Type: English Abstract, Journal Article)
|
| Chemical References |
- Antipsychotic Agents
- Piperazines
- Quinolones
- aripiprazole
|
| Topics |
- Adolescent
- Adult
- Antipsychotic Agents
(therapeutic use)
- Child
- Humans
- Motor Activity
(drug effects)
- Piperazines
(therapeutic use)
- Prospective Studies
- Quinolones
(therapeutic use)
- Tourette Syndrome
(drug therapy)
- Treatment Outcome
|
