Pharmacological evidence that 5-HT(1B/1D) receptors mediate hypotension in anesthetized rats.

Abstract	5-Carboxamidotryptamine (5-CT; 0.003-310 microg/kg, i.v.) produced dose-dependent hypotensive responses which were blocked in a complex manner by the 5-HT(7) receptor antagonist, (R)-1-[(3-hydroxyphenyl)sulfonyl]-2-[2-(4-methyl-1-piperidinyl) ethyl] pyrrolidine (SB-269970; 1 mg/kg, i.v.), in anesthetized vagosympathectomized rats. Interestingly, the 5-HT(1B/1D) receptor antagonist, N-[4-methoxy-3-(4-methyl-1-piperazinyl) phenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl) [1,1-biphenyl]-4-carboxamide hydrochloride monohydrate GR-127935 (1 mg/kg, i.v.), also inhibited 5-CT-induced hypotension but the effect was clearly noncompetitive. Finally, the combination of GR-127935+SB-269970 (1 mg/kg, i.v., each) produced a further decreased of 5-CT-induced responses as compared to the effect of individual treatments. These data suggest that, in addition to 5-HT(7) receptors, 5-HT(1B/1D) receptors may also mediate hypotension in rats.
Authors	José A Terrón, Carolina Sánchez-Maldonado, Esther Martínez-García
Journal	European journal of pharmacology (Eur J Pharmacol) Vol. 576 Issue 1-3 Pg. 132-5 (Dec 08 2007) ISSN: 0014-2999 [Print] Netherlands
PMID	17727836 (Publication Type: Journal Article)
Chemical References	5-HT(7) receptor, rat Oxadiazoles Phenols Piperazines Receptor, Serotonin, 5-HT1B Receptor, Serotonin, 5-HT1D Receptors, Serotonin SB 269970 Serotonin 5-HT1 Receptor Agonists Serotonin 5-HT1 Receptor Antagonists Serotonin Antagonists Serotonin Receptor Agonists Sulfonamides GR 127935 Serotonin 5-carboxamidotryptamine
Topics	Anesthesia Animals Blood Pressure (drug effects) Hypotension (physiopathology) Male Oxadiazoles (pharmacology) Phenols (pharmacology) Piperazines (pharmacology) Rats Rats, Wistar Receptor, Serotonin, 5-HT1B (physiology) Receptor, Serotonin, 5-HT1D (physiology) Receptors, Serotonin (physiology) Serotonin (analogs & derivatives, pharmacology) Serotonin 5-HT1 Receptor Agonists Serotonin 5-HT1 Receptor Antagonists Serotonin Antagonists (pharmacology) Serotonin Receptor Agonists (pharmacology) Sulfonamides (pharmacology)

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