| Abstract | 5-Carboxamidotryptamine (5-CT; 0.003-310 microg/kg, i.v.) produced dose-dependent hypotensive responses which were blocked in a complex manner by the 5-HT(7) receptor antagonist, (R)-1-[(3-hydroxyphenyl)sulfonyl]-2-[2-(4-methyl-1-piperidinyl) ethyl] pyrrolidine (SB-269970; 1 mg/kg, i.v.), in anesthetized vagosympathectomized rats. Interestingly, the 5-HT(1B/1D) receptor antagonist, N-[4-methoxy-3-(4-methyl-1-piperazinyl) phenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl) [1,1-biphenyl]-4-carboxamide hydrochloride monohydrate GR-127935 (1 mg/kg, i.v.), also inhibited 5-CT-induced hypotension but the effect was clearly noncompetitive. Finally, the combination of GR-127935+SB-269970 (1 mg/kg, i.v., each) produced a further decreased of 5-CT-induced responses as compared to the effect of individual treatments. These data suggest that, in addition to 5-HT(7) receptors, 5-HT(1B/1D) receptors may also mediate hypotension in rats. |
| Authors | José A Terrón, Carolina Sánchez-Maldonado, Esther Martínez-García
(Affiliation: Sección Externa de Farmacología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Apdo. Postal 14-740, Zacatenco 07000, México D.F., Mexico. jterron at cinvestav.mx)
|
| Journal | European journal of pharmacology
(Eur J Pharmacol)
Vol. 576
Issue 1-3
Pg. 132-5
(Dec 8 2007)
ISSN: 0014-2999 Netherlands |
| PMID | 17727836
(Publication Type: Journal Article)
|
| Chemical References |
- 5-HT(7) receptor, rat
- Oxadiazoles
- Phenols
- Piperazines
- Receptor, Serotonin, 5-HT1B
- Receptor, Serotonin, 5-HT1D
- Receptors, Serotonin
- SB 269970
- Serotonin Agonists
- Serotonin Antagonists
- Sulfonamides
- GR 127935
- Serotonin
- 5-carboxamidotryptamine
|
| Topics |
- Anesthesia
- Animals
- Blood Pressure
(drug effects)
- Hypotension
(physiopathology)
- Male
- Oxadiazoles
(pharmacology)
- Phenols
(pharmacology)
- Piperazines
(pharmacology)
- Rats
- Rats, Wistar
- Receptor, Serotonin, 5-HT1B
(agonists, antagonists & inhibitors, physiology)
- Receptor, Serotonin, 5-HT1D
(agonists, antagonists & inhibitors, physiology)
- Receptors, Serotonin
(physiology)
- Serotonin
(analogs & derivatives, pharmacology)
- Serotonin Agonists
(pharmacology)
- Serotonin Antagonists
(pharmacology)
- Sulfonamides
(pharmacology)
|
