Abstract | PURPOSE: METHODS: RESULTS: Induced liver necrosis caused significant elevation of activity of liver enzymes, parameters of oxidative stress and marked changes in histopathology, like necrosis of hepatocytes, hepatocyte degeneration and infiltration of inflammatory cells. In TPA and ST pretreated rats histopathological changes were almost absent, serum enzymes and oxidative stress parameters were decreased, while at the same time the concentration of reduced gluthathione was increased. CONCLUSION: The present findings suggest that treatment with TPA and ST for 7 weeks could be useful for the prevention of hepatic injury in rats.
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Authors | Snezana Uskoković-Marković, Marina Milenković, Aleksandra Topić, Jelena Kotur-Stevuljević, Aleksandra Stefanović, Jelena Antić-Stanković |
Journal | Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques
(J Pharm Pharm Sci)
Vol. 10
Issue 3
Pg. 340-9
( 2007)
ISSN: 1482-1826 [Electronic] Canada |
PMID | 17727797
(Publication Type: Journal Article)
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Chemical References |
- 12-tungstophosphoric acid
- Antioxidants
- Phosphoric Acids
- Tungsten Compounds
- Thioacetamide
- sodium tungstate(VI)
- Carbon Tetrachloride
- Glutathione
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Topics |
- Acute Disease
- Administration, Oral
- Animals
- Antioxidants
(pharmacology)
- Carbon Tetrachloride
- Disease Models, Animal
- Female
- Glutathione
(metabolism)
- Liver
(drug effects, pathology)
- Liver Function Tests
- Necrosis
(chemically induced, drug therapy, physiopathology)
- Oxidative Stress
(drug effects)
- Phosphoric Acids
(pharmacology)
- Rats
- Rats, Wistar
- Thioacetamide
- Tungsten Compounds
(pharmacology)
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