The use of levonorgestrel - IUD in the treatment of uterine myoma in Thai women.

Abstract

OBJECTIVE:

This study was designed to evaluate the potential usefulness of the levonorgestrel-releasing intrauterine device (LNG - IUD ; Mirena) in treating women with uterine myomas.

DESIGN:

Prospective before-and-after (comparing) study.

SETTING:

Department of Obstetrics and Gynecology King Chulalongkorn Memorial Hospital.

SUBJECTS:

Sixteen women with uterine myomas who intended to receive treatment with the LNG IUD.

INTERVENTION(S):

Clinical and ultrasound examinations were performed prior to and at 1, 3 and 6 months after the LNG IUD insertion.

MAIN OUTCOME MEASURES:

Myoma and Uterine volume, menstrual blood loss assessed with pictorial blood loss assessment charts and hematocrit.

RESULTS:

Use of the LNG IUD was associated with a statistically significant reduction in the total myoma volume, average uterine size and marked reduction in menstrual blood loss. After 6 months of use, the median total myoma volume decreased from 19.82 mL to 11.63 mL (p < 0.05), median pictorial blood loss assessment chart score declined from 89 to 3 (p < 0.05). Hematocrit level increased over 6 months of use. The most common side effects were bleeding disturbances (68.8%). No pregnancies occurred during the study.

CONCLUSION:

The LNG IUD was associated with a profound reduction in myoma and uterine volume. For women with myomas of this size, the LNG IUD provides effective medical treatment of bleeding.

• Authors: Kanok Jindabanjerd, Surasak Taneepanichskul
• Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet (J Med Assoc Thai) Vol. 89 Suppl 4 Pg. S147-51 (Oct 2006) ISSN: 0125-2208 [Print] Thailand
• PMID: 17726816 (Publication Type: Journal Article)

Chemical References

• Contraceptives, Oral, Synthetic
• Levonorgestrel

Topics

• Adult
• Contraceptives, Oral, Synthetic (adverse effects, therapeutic use)
• Female
• Humans
• Intrauterine Devices, Medicated
• Levonorgestrel (adverse effects, therapeutic use)
• Menstruation
• Middle Aged
• Myoma (drug therapy, physiopathology)
• Prospective Studies
• Thailand
• Time Factors
• Uterine Neoplasms (drug therapy, physiopathology)
• Uterus