| Abstract | (125)I-labeled anti-TAG-72 antibodies were applied in radioimmunoguided surgery (RIGS) to remove gross and occult tumors. It is challenging to handle (125)I-labeled materials. PET/CT image-guided surgery utilizes (18)FDG to monitor the biochemical activity of the tumor and to integrate pre- and postoperative imaging for complete tumor removal. PET/CT image-guided surgery only detects later stage disease. Fluorescence image-guided surgery using anti-TAG-72 antibodies may provide opportunities for intraoperative cancer detection of both gross and occult tumors. |
| Authors | Duxin Sun, Mark Bloomston, George Hinkle, Osama Habib Al-Saif, Nathan C Hall, Stephen P Povoski, Mark W Arnold, Edward W Martin Jr
(Affiliation: Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.)
|
| Journal | Journal of surgical oncology
(J Surg Oncol)
Vol. 96
Issue 4
Pg. 297-308
(Sep 15 2007)
ISSN: 0022-4790 United States |
| PMID | 17726663
(Publication Type: Journal Article)
|
| Chemical References |
- Antibodies, Monoclonal
- Antibodies, Neoplasm
- Antigens, Neoplasm
- B72.3 antibody
- Glycoproteins
- Iodine Radioisotopes
- Radiopharmaceuticals
- tumor-associated antigen 72
- Fluorodeoxyglucose F18
|
| Topics |
- Antibodies, Monoclonal
(drug effects)
- Antibodies, Neoplasm
(drug effects)
- Antigens, Neoplasm
(immunology)
- Colorectal Neoplasms
(pathology, radiography, radionuclide imaging, surgery)
- Fluorescence
- Fluorodeoxyglucose F18
(diagnostic use)
- Forecasting
- Gamma Cameras
- Glycoproteins
(immunology)
- Humans
- Iodine Radioisotopes
(diagnostic use)
- Neoplasm Staging
- Positron-Emission Tomography
- Radioimmunodetection
(trends)
- Radiopharmaceuticals
(diagnostic use)
- Surgery, Computer-Assisted
(trends)
- Survival Analysis
- Tomography, X-Ray Computed
|
