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Beta2-chimaerin in cancer signaling: connecting cell adhesion and MAP kinase activation.

Abstract
The chimaerins are Rac GTPase-activating proteins that bind diacylglycerol. Emerging evidence implicates beta2-chimaerin in tumor progression. Here, we discuss our recent work in Drosophila melanogaster in the context of previous studies performed in human cancer cell lines that together lend new mechanistic insight into the role of chimaerins in cancer.
AuthorsStephen P Bruinsma, Thomas J Baranski
JournalCell cycle (Georgetown, Tex.) (Cell Cycle) Vol. 6 Issue 20 Pg. 2440-4 (Oct 15 2007) ISSN: 1551-4005 [Electronic] United States
PMID17726379 (Publication Type: Journal Article)
Chemical References
  • Neoplasm Proteins
  • beta-chimaerin
  • Mitogen-Activated Protein Kinases
Topics
  • Animals
  • Cell Adhesion
  • Disease Progression
  • Enzyme Activation
  • Humans
  • Mitogen-Activated Protein Kinases (metabolism)
  • Neoplasm Proteins (metabolism)
  • Neoplasms (metabolism, pathology)
  • Signal Transduction

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