Use of Glubran 2 acrylic glue in interventional neuroradiology.

Abstract

INTRODUCTION:

Glubran 2 is a cyanoacrylate-based synthetic glue modified by the addition of a monomer synthesized by the manufacturer. With this material it is possible to obtain the stability of endovascular embolization that is needed to treat tumours and vascular disease.

MATERIAL AND METHODS:

We report our 3-year experience of the use of Glubran for treating extracerebral tumours, spinal tumours, spinal arteriovenous malformations, and brain and spine dural fistulae. Glubran 2 was diluted with Lipiodol and injected in a continuous column with the flow rate monitored by seriography. The injection was stopped when retrograde flow was displayed in the afferent vessel.

RESULTS:

There were no periprocedural or subsequent clinical complications and the glue resulted in successful selective permanent occlusion with intralesional penetration similar to the angiographic features of microcatheterization.

CONCLUSIONS:

The embolization procedure was technically straightforward and relatively safe. However, Glubran 2 can be difficult to use and the procedure does carry major risks for patients. Glue injection requires in-depth study of the lesion, its circulation and the collateral circulation to avoid severe complications due to inappropriate use.

• Authors: L Raffi, L Simonetti, P Cenni, M Leonardi
• Journal: Neuroradiology (Neuroradiology) Vol. 49 Issue 10 Pg. 829-36 (Oct 2007) ISSN: 1432-1920 [Electronic] Germany
• PMID: 17724584 (Publication Type: Journal Article)

Chemical References

• Cyanoacrylates
• Tissue Adhesives
• glubran 2

Topics

• Adult
• Aged
• Brain Diseases (diagnosis, therapy)
• Cerebral Angiography
• Cyanoacrylates (administration & dosage)
• Embolization, Therapeutic (methods)
• Female
• Humans
• Male
• Middle Aged
• Spinal Diseases (diagnosis, therapy)
• Tissue Adhesives (administration & dosage)