Abstract |
Adenosine is one of the inhibitory neuromodulators in the brain. The present study was carried out to elucidate the effect of adenosine on the pentylenetetrazol (PTZ)-induced seizure threshold in mice. Further, the study also correlated the brain adenosine levels in PTZ-induced seizure threshold. PTZ (0.5%, w/v) was infused through lateral tail vein of mouse at a constant rate of 0.3 ml/min until various stages of convulsions were observed. Minimal dose of PTZ (mg/kg) needed to induce different phases (myoclonic jerks, generalized clonus and tonic extensor) of PTZ convulsions were noted as an index of seizure threshold. Intravenous infusion of PTZ resulted in a significant decrease in brain adenosine levels. Systemic administration of adenosine (100 and 200 mg/kg, i.p.), 30 min before PTZ infusion, produced a dose-dependent elevation of PTZ-seizure threshold and also enhanced brain adenosine levels as compared to vehicle treated group. The behavioral and neurochemical observations demonstrated a relationship between adenosine levels in the brain and the PTZ seizure threshold in mice.
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Authors | Kiran Kumar Akula, Ashish Dhir, Mahendra Bishnoi, S K Kulkarni |
Journal | Neuroscience letters
(Neurosci Lett)
Vol. 425
Issue 1
Pg. 39-42
(Sep 20 2007)
ISSN: 0304-3940 [Print] Ireland |
PMID | 17720312
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Vasodilator Agents
- Adenosine
- Pentylenetetrazole
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Topics |
- Adenosine
(administration & dosage, metabolism)
- Analysis of Variance
- Animals
- Brain
(drug effects, metabolism)
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Drug Administration Routes
- Male
- Mice
- Pentylenetetrazole
- Seizures
(chemically induced, drug therapy, pathology, physiopathology)
- Time Factors
- Vasodilator Agents
(administration & dosage, metabolism)
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