| Abstract | This study investigated whether a microbubble-containing ultrasound contrast agent had a role in the antivascular action of physiotherapy ultrasound on tumor neovasculature. Ultrasound images (B-mode and contrast-enhanced power Doppler [0.02 mL Definity]) were made of 22 murine melanomas (K1735(22)). The tumor was insonated (I(SATA) = 1.7 W cm(-2), 1 MHz, continuous output) for 3 min and the power Doppler observations of the pre- and postinsonation tumor vascularities were analyzed. Significant reductions (p = 0.005 for analyses of color-weighted fractional area) in vascularity occurred when a contrast-enhanced power Doppler study occurred before insonation. Vascularity was unchanged in tumors without a pretherapy Doppler study. Histologic studies revealed tissue structural changes that correlated with the ultrasound findings. The underlying etiology of the interaction between the physiotherapy ultrasound beam, the microbubble-containing contrast agent and the tumor neovasculature is unknown. It was concluded that contrast agents play an important role in the antivascular effects induced by physiotherapy ultrasound. |
| Authors | Andrew K W Wood, Ralph M Bunte, Jennie D Cohen, Jeff H Tsai, William M-F Lee, Chandra M Sehgal
(Affiliation: Department Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.)
|
| Journal | Ultrasound in medicine & biology
(Ultrasound Med Biol)
Vol. 33
Issue 12
Pg. 1901-10
(Dec 2007)
ISSN: 0301-5629 England |
| PMID | 17720299
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
|
| Chemical References |
- Contrast Media
- Definity
- Fluorocarbons
|
| Topics |
- Animals
- Contrast Media
(therapeutic use)
- Female
- Fluorocarbons
(therapeutic use)
- Melanoma, Experimental
(blood supply, pathology, therapy, ultrasonography)
- Mice
- Mice, Inbred C3H
- Microbubbles
- Neoplasm Transplantation
- Neovascularization, Pathologic
(pathology, therapy, ultrasonography)
- Ultrasonic Therapy
(methods)
- Ultrasonography, Doppler
(methods)
|
