[Study on mechanism of biminne in treating allergic rhinitis].

Abstract

OBJECTIVE:

To investigate the effect and mechanism of Biminne, a Chinese herbal compound preparation, for treatment of allergic rhinitis (AR).

METHODS:

AR model of mouse was induced by intraperitoneal injection of ovalbumin (OVA), and the changes in behavior, proliferative activity of splenic lymphocyte, serum levels of total IgE and OVA specific IgE were observed.

RESULTS:

Biminne showed effects in reducing the frequency of sneezing and nasal rubbing, inhibiting the proliferation of splenic lymphocyte stimulated by phyto-hemagglutinin (PHA) and OVA, and lowering the levels of serum total IgE and OVA specific IgE.

CONCLUSION:

Biminne could inhibit the proliferation of splenic lymphocyte and reduce serum level of IgE in mice with AR.

• Authors: Run-hong Liu, Xin-min Zhang, Su-qin Zhang
• Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine (Zhongguo Zhong Xi Yi Jie He Za Zhi) Vol. 27 Issue 7 Pg. 623-5 (Jul 2007) ISSN: 1003-5370 [Print] China
• PMID: 17717923 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Drugs, Chinese Herbal
• Immunoglobulin E
• Ovalbumin

Topics

• Animals
• Cell Proliferation
• Drugs, Chinese Herbal (therapeutic use)
• Immunoglobulin E (blood)
• Lymphocytes (drug effects, immunology, pathology)
• Male
• Mice
• Mice, Inbred BALB C
• Ovalbumin
• Phytotherapy
• Random Allocation
• Rhinitis, Allergic, Perennial (chemically induced, drug therapy, immunology)