Abstract |
Lutein and zeaxanthin are xanthophyll carotenoids with potent antioxidant properties protecting the skin from acute photodamage. This study extended the investigation to chronic photodamage and photocarcinogenesis. Mice received either a lutein/ zeaxanthin-supplemented diet or a standard nonsupplemented diet. Dorsal skin of female Skh-1 hairless mice was exposed to UVB radiation with a cumulative dose of 16,000 mJ/cm(2) for photoaging and 30,200 mJ/cm(2) for photocarcinogenesis. Clinical evaluations were performed weekly, and the animals were sacrificed 24 h after the last UVB exposure. For photoaging experiments, skin fold thickness, suprapapillary plate thickness, mast cell counts and dermal desmosine content were evaluated. For photocarcinogenesis, samples of tumors larger than 2 mm were analyzed for histological characterization, hyperproliferation index, tumor multiplicity, total tumor volume and tumor-free survival time. Results of the photoaging experiment revealed that skin fold thickness and number of infiltrating mast cells following UVB irradiation were significantly less in lutein/ zeaxanthin-treated mice when compared to irradiated animals fed the standard diet. The results of the photocarcinogenesis experiment were increased tumor-free survival time, reduced tumor multiplicity and total tumor volume in lutein/ zeaxanthin-treated mice in comparison with control irradiated animals fed the standard diet. These data demonstrate that dietary lutein/ zeaxanthin supplementation protects the skin against UVB-induced photoaging and photocarcinogenesis.
|
Authors | S Astner, A Wu, J Chen, N Philips, F Rius-Diaz, C Parrado, M C Mihm, D A Goukassian, M A Pathak, S González |
Journal | Skin pharmacology and physiology
(Skin Pharmacol Physiol)
Vol. 20
Issue 6
Pg. 283-91
( 2007)
ISSN: 1660-5535 [Electronic] Switzerland |
PMID | 17717424
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | (c) 2007 S. Karger AG, Basel. |
Chemical References |
- Xanthophylls
- Zeaxanthins
- Desmosine
- Lutein
|
Topics |
- Animals
- Desmosine
(metabolism)
- Diet
- Lutein
(administration & dosage)
- Mast Cells
(drug effects, immunology, radiation effects)
- Mice
- Mice, Hairless
- Skin
(drug effects, pathology, physiopathology, radiation effects)
- Skin Aging
(drug effects, immunology, pathology)
- Skin Neoplasms
(etiology, pathology, prevention & control)
- Tumor Burden
(drug effects)
- Ultraviolet Rays
(adverse effects)
- Xanthophylls
(administration & dosage)
- Zeaxanthins
|