Topical atropine sulfate for the treatment of axillary hyperhidrosis.

Abstract

BACKGROUND:

Axillary hyperhidrosis does not have a low-cost, free of secondary effects, satisfactory treatment. Eccrine hidrocystomas have been successfully treated with topical atropine solution. Hypothesis Axillary hyperhidrosis could respond to the topical application of atropine solution.

METHODS:

Ten patients were selected. Eight with mild pure primary axillary hyperhidrosis and two with compensatory sweating after sympathectomy. One milliliter of a water solution of atropine sulfate at 1% was applied twice a day over the affected area and massaged for 30 s. Treatment was maintained for 15 days. The results were rated using a scale from 1 to 10 of satisfaction.

RESULTS:

Only 2 of the 10 treated patients responded partially to the topical application of atropine sulfate. No local or systemic secondary effects were observed.

CONCLUSIONS:

The results of the study demonstrated that focal hyperhidrosis does not improve after the local application of anticholinergic drugs such as atropine sulfate.

• Authors: Ramon Grimalt, Patricia Domínguez Tordera, Marco A Callejas
• Journal: Journal of cosmetic dermatology (J Cosmet Dermatol) Vol. 5 Issue 4 Pg. 294-6 (Dec 2006) ISSN: 1473-2165 [Electronic] England
• PMID: 17716247 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Muscarinic Antagonists
• Atropine

Topics

• Abdomen
• Administration, Cutaneous
• Atropine (administration & dosage, therapeutic use)
• Axilla
• Female
• Humans
• Hyperhidrosis (drug therapy)
• Male
• Muscarinic Antagonists (administration & dosage, therapeutic use)
• Patient Satisfaction
• Treatment Failure