Rheumajecta and vasolastine in the treatment of rheumatoid arthritis--the results of a placebo-controlled, double-blind trial of a complementary treatment.

Abstract	The so called "enzymatic preparations" Rheumajecta and Vasolastine (R & V) belong to the complementary treatments. The preparations have been used for many years in the treatment of patients with rheumatic conditions such as rheumatoid arthritis (RA) in the Netherlands and other countries of Europe, although a proper study showing efficacy was never performed. Therefore a double-blind, placebo-controlled, modified cross-over trial during two periods of 3 months was performed in 34 patients with RA. They were allocated at random to R & V or to placebo injections, all intramuscular. After 3 months of therapy each patient could opt for cross-over in the event of lack of subjective improvement. Clinical assessments including Ritchie's articular index, grip strength, the DUTCH-AIMS questionnaire, ESR and CRP were performed. R & V did not prove to be more effective than placebo. No serious side-effects were seen.
Authors	J W Jacobs, J J Rasker, P L van Riel, F W Gribnau, L B van de Putte
Journal	Scandinavian journal of rheumatology (Scand J Rheumatol) Vol. 20 Issue 6 Pg. 434-40 ( 1991) ISSN: 0300-9742 [Print] England
PMID	1771401 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References	Drug Combinations Rheumajecta vasoelastine Catalase Lipoxygenase Choline O-Acetyltransferase Sulfate Adenylyltransferase Sulfurtransferases Lipase
Topics	Adolescent Adult Aged Arthritis, Rheumatoid (drug therapy, pathology, physiopathology) Catalase (administration & dosage, standards, therapeutic use) Choline O-Acetyltransferase (administration & dosage, standards, therapeutic use) Double-Blind Method Drug Combinations Drug Therapy, Combination Female Humans Injections, Intramuscular Lipase (administration & dosage, standards, therapeutic use) Lipoxygenase (administration & dosage, standards, therapeutic use) Male Middle Aged Severity of Illness Index Sulfate Adenylyltransferase (administration & dosage, standards, therapeutic use) Sulfurtransferases (administration & dosage, standards, therapeutic use) Surveys and Questionnaires

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