Alveolar epithelial beta2-adrenergic receptors.

Abstract

beta(2)-adrenergic receptors are present throughout the lung, including the alveolar airspace, where they play an important role for regulation of the active Na(+) transport needed for clearance of excess fluid out of alveolar airspace. beta(2)-adrenergic receptor signaling is required for up-regulation of alveolar epithelial active ion transport in the setting of excess alveolar edema. The positive, protective effects of beta(2)-adrenergic receptor signaling on alveolar active Na(+) transport in normal and injured lungs provide substantial support for the use of beta-adrenergic agonists to accelerate alveolar fluid clearance in patients with cardiogenic and noncardiogenic pulmonary edema. In this review, we summarize the role of beta(2)-adrenergic receptors in the alveolar epithelium with emphasis on their role in the regulation of alveolar active Na(+) transport in normal and injured lungs.

• Authors: Gökhan M Mutlu, Phillip Factor
• Journal: American journal of respiratory cell and molecular biology (Am J Respir Cell Mol Biol) Vol. 38 Issue 2 Pg. 127-34 (Feb 2008) ISSN: 1535-4989 [Electronic] United States
• PMID: 17709598 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Adrenergic beta-2 Receptor Agonists
• Adrenergic beta-Agonists
• Receptors, Adrenergic, beta-2

Topics

• Adrenergic beta-2 Receptor Agonists
• Adrenergic beta-Agonists (therapeutic use)
• Animals
• Humans
• Protein Conformation
• Pulmonary Alveoli (metabolism)
• Pulmonary Edema (drug therapy)
• Receptors, Adrenergic, beta-2 (chemistry, metabolism)
• Signal Transduction