Abstract | OBJECTIVE: The objective of this study was to evaluate the biological behaviors of a novel (188)Re-labeled meso-tetrakis(4-sulfophenyl)porphyrin ( TPPS(4)) in normal mice and tumor-bearing mice. METHODS:
TPPS(4) was synthesized and labeled by (188)ReO(4)(-). Normal KM mice and BALB/c nude mice bearing melanoma or hepatoma were prepared for distribution studies. RESULTS: The [(188)Re] TPPS(4) yield was >98% with a specific activity of 11.2 GBq/mol, and vitamin C could increase its stability in vitro. In normal KM mice, [(188)Re] TPPS(4) had a fast blood clearance ( approximately 90%, 24 h postinjection), low retention in vital organs and hepatotropic characteristics. In nude mice, uptakes of >4.1% and 6.5% ID/g tumor at 8 h postinjection were observed in melanoma and hepatoma, respectively; this remained at high levels of 4.7% and 5.7%, respectively, after 24 h. At 8 h, the tumor/blood and tumor/muscle ratios in melanoma-bearing and hepatoma-bearing mice were 6.2-15.2 and 6.1-24.2, respectively. Twenty-four hours later, these high ratios still continued at 8.6-22.1 and 12-26.1, respectively. CONCLUSION: The results obtained in this study indicate that [(188)Re] TPPS(4) has a high tumor affinity and retainable accumulation characteristics in carcinoma, which can potentially be used for tumor-targeted therapy.
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Authors | Zhiyun Jia, Houfu Deng, Manfei Pu |
Journal | Nuclear medicine and biology
(Nucl Med Biol)
Vol. 34
Issue 6
Pg. 643-9
(Aug 2007)
ISSN: 0969-8051 [Print] United States |
PMID | 17707804
(Publication Type: Journal Article)
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Chemical References |
- Indicators and Reagents
- Metalloporphyrins
- Radioisotopes
- Radiopharmaceuticals
- rhenium tetrakis(4-sulfophenyl)porphyrin
- Rhenium
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Topics |
- Animals
- Chromatography, High Pressure Liquid
- Hydrogen-Ion Concentration
- Indicators and Reagents
- Isotope Labeling
- Liver Neoplasms, Experimental
(metabolism)
- Melanoma, Experimental
(metabolism)
- Metalloporphyrins
(chemical synthesis)
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Radioisotopes
- Radiopharmaceuticals
(chemical synthesis)
- Rhenium
- Tissue Distribution
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