Abstract | PURPOSE: MATERIALS AND METHODS: Timed pregnant C57BL/6 mice were administered benzophenone-2 (6.25 mg) or control vehicle by oral gavage from gestational days 12 through 17 and they were sacrificed on day 18. Fetuses were weighed and sexed, anogenital distance was measured and genital tubercles were harvested for paraffin sections or quantitative reverse transcriptase-polymerase chain reaction analysis of genes purportedly involved in genital tubercle development. RESULTS: CONCLUSIONS:
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Authors | Michael H Hsieh, Erin C Grantham, Benchun Liu, Reginald Macapagal, Emily Willingham, Laurence S Baskin |
Journal | The Journal of urology
(J Urol)
Vol. 178
Issue 4 Pt 2
Pg. 1637-42
(Oct 2007)
ISSN: 0022-5347 [Print] United States |
PMID | 17707034
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Benzophenones
- Receptors, Estrogen
- 2,2',4,4'-tetrahydroxybenzophenone
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Topics |
- Analysis of Variance
- Animals
- Benzophenones
(toxicity)
- Female
- Genitalia, Male
(embryology, metabolism)
- Hypospadias
(chemically induced, embryology)
- Male
- Mice
- Mice, Inbred C57BL
- Pregnancy
- Prenatal Exposure Delayed Effects
- Receptors, Estrogen
(drug effects)
- Reverse Transcriptase Polymerase Chain Reaction
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