Abstract | BACKGROUND: METHODS: Of the 7788 Digitalis Investigation Group participants, 4036 were >or=65 years and 3271 (81%) were receiving diuretics. Propensity scores for diuretic use for each of the 4036 patients were calculated using a non-parsimonious multivariable logistic regression model incorporating all measured baseline covariates, and were used to match 651 (85%) patients not receiving diuretics with 651 patients receiving diuretics. Effects of diuretics on mortality and hospitalization at 37 months of median follow-up were assessed using matched Cox regression models. RESULTS: All-cause mortality occurred in 173 patients not receiving diuretics and 208 patients receiving diuretics respectively during 2056 and 1943 person-years of follow-up (hazard ratio {HR}=1.36; 95% confidence interval {CI}=1.08-1.71; p=0.009). All-cause hospitalizations occurred in 413 patients not receiving and 438 patients receiving diuretics respectively during 1255 and 1144 person-years of follow-up (HR=1.18; 95% CI=0.99-1.39; p=0.063). Diuretic use was associated with significant increased risk of cardiovascular mortality (HR=1.50; 95% CI=1.15-1.96; p=0.003).and heart failure hospitalization (HR=1.48; 95% CI=1.13-1.94; p=0.005). CONCLUSIONS:
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Authors | Ali Ahmed, James B Young, Thomas E Love, Raynald Levesque, Betram Pitt |
Journal | International journal of cardiology
(Int J Cardiol)
Vol. 125
Issue 2
Pg. 246-53
(Apr 10 2008)
ISSN: 1874-1754 [Electronic] Netherlands |
PMID | 17706809
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
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Topics |
- Aged
- Aged, 80 and over
- Diuretics
(administration & dosage, adverse effects)
- Female
- Follow-Up Studies
- Heart Failure
(drug therapy, mortality)
- Hospital Mortality
(trends)
- Hospitalization
(trends)
- Humans
- Male
- Multicenter Studies as Topic
(trends)
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