Iloprost infusion does not reduce oxidative stress in systemic sclerosis.

Abstract

Systemic sclerosis is a connective tissue disease in which oxidative stress represents an important player among the complex pathogenetic mechanisms of the disease. Iloprost, an analogue of natural prostacyclin, is used in systemic sclerosis for the treatment of severe Raynaud's phenomenon and ischemic ulcers. There is a clear evidence that iloprost attenuates oxidative damage induced by ischemia-reperfusion phenomena. The aim of this study is to evaluate the effect of iloprost on oxidative status in ten patients with systemic sclerosis by measuring urinary levels of 8-isoprostaglandin-F(2alpha), a member of F(2)-isoprostanes. We found that systemic sclerosis patients cyclically treated with iloprost showed increased urinary level of 8-isoprostaglandin-F(2alpha )in comparison with healthy subjects; urinary 8-isoprostaglandin-F(2alpha) did not diminish soon after the iloprost infusion as well as 3, 15 and 30 days after the drug administration. Unlike experimental studies, in vivo the strong vasodilator effect of iloprost infusion did not reduce oxidative status.

• Authors: Alessandro Volpe, Domenico Biasi, Paola Caramaschi, Lisa Maria Bambara, Antonio Carletto, Maurizio Degan, Pietro Minuz
• Journal: Rheumatology international (Rheumatol Int) Vol. 28 Issue 4 Pg. 335-7 (Feb 2008) ISSN: 0172-8172 [Print] Germany
• PMID: 17704920 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Vasodilator Agents
• 8-epi-prostaglandin F2alpha
• Dinoprost
• Iloprost

Topics

• Dinoprost (analogs & derivatives, urine)
• Female
• Humans
• Iloprost (administration & dosage)
• Infusions, Parenteral
• Male
• Middle Aged
• Oxidative Stress (drug effects)
• Scleroderma, Systemic (drug therapy, metabolism)
• Time Factors
• Treatment Outcome
• Up-Regulation
• Vasodilator Agents (administration & dosage)