Abstract | BACKGROUND AND PURPOSE: The present study addressed the effects of the investigational PDE4 inhibitor roflumilast on leukocyte-endothelial cell interactions and endothelial permeability in vivo and in vitro. EXPERIMENTAL APPROACH: KEY RESULTS: CONCLUSIONS AND IMPLICATIONS: These findings further support earlier observations on the inhibition of inflammatory cell influx and protein extravasation by roflumilast in vivo.
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Authors | M-J Sanz, J Cortijo, M A Taha, M Cerdá-Nicolás, E Schatton, B Burgbacher, J Klar, H Tenor, C Schudt, A C Issekutz, A Hatzelmann, E J Morcillo |
Journal | British journal of pharmacology
(Br J Pharmacol)
Vol. 152
Issue 4
Pg. 481-92
(Oct 2007)
ISSN: 0007-1188 [Print] England |
PMID | 17704822
(Publication Type: Journal Article)
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Chemical References |
- Aminopyridines
- Benzamides
- CD11b Antigen
- Cell Adhesion Molecules
- Cyclopropanes
- Lipopolysaccharides
- Phosphodiesterase Inhibitors
- RNA, Messenger
- Selectins
- Tumor Necrosis Factor-alpha
- Roflumilast
- roflumilast N-oxide
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Topics |
- Aminopyridines
(pharmacology)
- Animals
- Benzamides
(pharmacology)
- CD11b Antigen
(metabolism)
- Capillary Permeability
(drug effects)
- Cell Adhesion
(drug effects)
- Cell Adhesion Molecules
(genetics, metabolism)
- Cell Communication
(drug effects)
- Cell Line
- Cells, Cultured
- Cyclopropanes
(pharmacology)
- Dose-Response Relationship, Drug
- Endothelial Cells
(cytology, drug effects, metabolism)
- Humans
- Leukocytes
(cytology, drug effects)
- Lipopolysaccharides
(antagonists & inhibitors, pharmacology)
- Male
- Mesenteric Veins
(chemistry, drug effects, metabolism)
- Neutrophils
(cytology, drug effects, metabolism)
- Phosphodiesterase Inhibitors
(pharmacology)
- RNA, Messenger
(genetics, metabolism)
- Rats
- Rats, Sprague-Dawley
- Reverse Transcriptase Polymerase Chain Reaction
- Selectins
(genetics, metabolism)
- Tumor Necrosis Factor-alpha
(pharmacology)
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