Abstract | BACKGROUND: METHODS: We examined the expression levels of onfFN mRNA in ATC tissues and cell lines derived from ATC by real-time quantitative reverse transcription-polymerase chain reaction (PCR) and in situ hybridization. RESULTS: Increased expression of onfFN mRNA was observed in all cases of ATC regardless of the type of accompanying differentiated carcinoma and five of six ATC cell lines. Furthermore, expression of onfFN mRNA was observed in the majority of ATC cells in all six tissues examined by in situ hybridization. CONCLUSION:
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Authors | Toru Takano, Yasuhiro Ito, Fumio Matsuzuka, Akihiro Miya, Kaoru Kobayashi, Hiroshi Yoshida, Akira Miyauchi |
Journal | Japanese journal of clinical oncology
(Jpn J Clin Oncol)
Vol. 37
Issue 9
Pg. 647-51
(Sep 2007)
ISSN: 1465-3621 [Electronic] England |
PMID | 17704536
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers, Tumor
- Fibronectins
- RNA, Messenger
- oncofetal fibronectin
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Topics |
- Biomarkers, Tumor
(analysis, genetics)
- Carcinoma
(chemistry)
- Cell Line, Tumor
- Fibronectins
(analysis, genetics)
- Gene Expression Regulation, Neoplastic
- Humans
- In Situ Hybridization
- RNA, Messenger
(analysis)
- Reverse Transcriptase Polymerase Chain Reaction
- Thyroid Gland
(chemistry)
- Thyroid Neoplasms
(chemistry)
- Up-Regulation
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