Commentary on: Mas JL, Chatellier G, Beyssen B, et al. Endarterectomy versus stenting in patients with symptomatic severe carotid stenosis. N Engl J Med. 2006;355:1660-1671.

Abstract

BACKGROUND:

Carotid stenting is less invasive than endarterectomy, but it is unclear whether it is as safe in patients with symptomatic carotid-artery stenosis.

METHODS:

We conducted a multicenter, randomized, non-inferiority trial to compare stenting with endarterectomy in patients with a symptomatic carotid stenosis of at least 60%. The primary end point was the incidence of any stroke or death within 30 days after treatment.

RESULTS:

The trial was stopped prematurely after the inclusion of 527 patients for reasons of both safety and futility. The 30-day incidence of any stroke or death was 3.9% after endarterectomy (95% confidence interval [CI], 2.0-7.2) and 9.6% after stenting (95% CI, 6.4-14.0); the relative risk of any stroke or death after stenting as compared with endarterectomy was 2.5 (95% CI, 1.2-5.1). The 30-day incidence of disabling stroke or death was 1.5% after endarterectomy (95% CI, 0.5-4.2) and 3.4% after stenting (95% CI, 1.7-6.7); the relative risk was 2.2 (95% CI, 0.7-7.2). At 6 months, the incidence of any stroke or death was 6.1% after endarterectomy and 11.7% after stenting (P = .02). There were more major local complications after stenting and more systemic complications (mainly pulmonary) after endarterectomy, but the differences were not significant. Cranial-nerve injury was more common after endarterectomy than after stenting.

CONCLUSIONS:

In this study of patients with symptomatic carotid stenosis of 60% or more, the rates of death and stroke at 1 and 6 months were lower with endarterectomy than with stenting.

• Authors: Richard P Cambria
• Journal: Perspectives in vascular surgery and endovascular therapy (Perspect Vasc Surg Endovasc Ther) Vol. 19 Issue 2 Pg. 201-3 (Jun 2007) ISSN: 1531-0035 [Print] United States
• PMID: 17704496 (Publication Type: Comparative Study, Journal Article)

Topics

• Carotid Stenosis (therapy)
• Endarterectomy, Carotid
• Humans
• Prospective Studies
• Randomized Controlled Trials as Topic
• Stents